Integrated Drug Discovery

Offering End-to-End Solutions

Hit Identification / Characterization

Axcelead will design a robust HTS strategy, starting from assay development through hit characterization, based on 700+ HTS experiences. Using carefully curated library sets from 1.5 million compounds inherited from a pharmaceutical company, we have achieved a success hit identification rate of 90+%. We also focus on advancing hit compounds to development candidates efficiently. Annotation information from our database, medicinal chemist reviews, and high-throughput ADME tests can be utilized for hit prioritization. Through evaluating similar compounds from our compound library and utilizing high-throughput synthesis platform, we will prioritize the best hit chemotypes ensuring quality Lead Generation start.

  • Compound Libraries
  • Virtual Screening
  • Target-Based High-Throughput Screening (HTS)
    – Biochemical & Mass Spectrometry-Based Assay
    – Cellular Assay
    – Affinity Selection Mass Spectrometry (ASMS) 
    – Thermal Shift Assay (TSA) 
    – Fragment Based Drug Discovery (FBDD)
  • Phenotypic Screening
    – Phenotypic Assay 
    – iPSC 
    – Target Deconvolution
  • New Modalities
    – Targeted Protein Degradation 
    – RNA Targeting Drug 
  • Hit Characterization
    – Hit Expansion & High-Throughput Synthesis
    – Structural Biology & Biophysics 

We are ready to partner with you.