Technology Platforms

High Throughput Screening

We Can Help You Create Truly Novel, Original Drugs

Our integrated High Throughput Screening (HTS) platform, including a pharma-origin library of 1.5 million compounds, assay development capabilities, and a track record of over 700 projects, helps you rapidly identify your hit compounds.

  • We help you identify original and proprietary hits through our 1.5 million compound library, which originates from a pharmaceutical company and includes 60% internally synthesized compounds
  • We can design an efficient hit identification process and prioritize hits by leveraging our accumulated proprietary data
  • Our faster, pharma-standard HTS can significantly contribute to reduce drug discovery timeline

Our Full Capabilities in HTS

We have a lot to offer with screening services aimed at identifying new chemical matter. Our team provides high-quality and cost-effective screening services covering a wide range of assay technologies.

Track Record and Experimental Data

Over
90%
Hit Ratio of Screening
Experimental
data for
989
individual targets
are available
Over
700
track records of HTS projects

Assay Development

We regularly invest in the best assays and platform technologies to support our customers’ needs in screening activities.

  • Offers efficient material preparation and assay development services that enable swift transition to LG/LO stages
  • Achieved over 480 track records of assay development, over 80% developed at Axcelead

Typical assay menu examples

Enzyme
– Luminescence, Absorbance, Coupling, Fluorescence, TR-FRET, AlphaScreen
– Label-free assay (Rapidfire-MS)
– ELISA
– Radiometric assay

Protein/Protein Interaction
– TR-FRET, AlphaScreen
– ELISA
– NanoBit, NanoBRET
– Two-hybrid assay
– Biophysical assay

Nucleic Acids
– Biophysical assay (e.g. ASMS)
– Fluorescence probe binding
– FRET
– Cell-based assay (Reporter gene, RT-qPCR)

GPCR
– cAMP assay
– Ca2+ flux assay (FLIPR, FDSS)
– Reporter gene assay
– Arrestin/Internalization assays
– Binding assay

Ion channel / Transporter
– Ion influx assay
– Membrane potential
– Electrophysiology
– Substrate uptake
– Binding

Nuclear Receptor
– Binding assay
– Cofactor recruitment assay
– Reporter gene assay
– Nuclear translocation assay

Phenotype
– High content imaging assay
– Reporter gene assay, qRT-PCR
– Cell growth, etc.

Biophysics
– SPR
– ASMS
– ITC
– Thermal Shift
– Crystal structure

We have comprehensive assay development capability and experience. Please inquire if your assay menu of interest is not covered in this list.

Compound Libraries

  • A pharma-origin, high-quality library of 1.5 million compounds, with 60% originally designed and synthesized compounds
  • Diversity library up to 500K compounds
  • Focused libraries to support specific needs

Hit Expansion and Hit-to-lead

  • Quickly obtain Structure Activity Relationship (SAR) by similar compounds assay selected from 1.5 million compound library and/or high throughput synthesis
  • Determine priority hit compounds by HT-ADMET profiling and assessment by experienced medicinal chemists
  • Expand hit compounds to lead rapidly with our full chemistry capabilities and in-silico system

We are ready to partner with you.