Yujiro Uchino of the Drug Discovery Chemistry Business Unit to Present at the 43rd Medicinal Chemistry Symposium

2026.11.04

Yujiro Uchino of the Drug Discovery Chemistry Business Unit will present a poster at The 43rd Medicinal Chemistry Symposium, to be held at Kyoto terrsa, Kyoto, Japan. If you plan to attend the conference, we encourage you to join the session and hear the presentation.

Conference Name: The 43rd Medicinal Chemistry Symposium

Date & Time: November 12, 2026 (Saturday), 4:30–6:00 p.m.

Location: Kyoto Terrsa, Kyoto, Japan

Title: Late-Stage Functionalization for the Expansion of Chemical Space in Bioactive Compounds

Poster No.: 3P-32

Presentation Summary
Lead optimization in drug discovery often involves structurally complex compounds including multiple heteroaromatic rings and diverse functional groups. Applying Late-Stage Functionalization (LSF), in which functional groups are introduced or transformed at a late stage of synthesis, to such compounds presents challenges in predicting reactivity and site selectivity, as well as in separating and identifying the resulting products.
In this presentation, we will showcase successful examples in which marketed drugs were used as model substrates to generate structurally diverse derivatives with different substitution patterns and functional groups through LSF.
We will also discuss the practical challenges associated with incorporating LSF into the drug discovery workflow and our efforts to address them.

Axcelead’s Soulution
Axcelead provides one-stop support for drug discovery research, from compound design and synthesis to evaluation. The Late-Stage Functionalization (LSF) approach enables the efficient generation of diverse derivatives from active compounds, helping to accelerate lead optimization. If you face any challenges in medicinal chemistry, please feel free to contact us.