Publications Archives - Axcelead

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Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective Anti-Cancer Drug

ACS Medicinal Chemistry Letters

Junko Yokoi2026-07-07T04:03:52+00:0006.23.2026|

Cross-organ multi-omics profiling of microbiome and metabolome along the gut-liver axis in MASH model mice induced by western diet and MC4R knockout

Gut Pathogens

Junko Yokoi2026-05-07T07:44:25+00:0004.01.2026|

Investigation of storage conditions and quality control markers for metabolites and lipids in human feces

Metabolites

Junko Yokoi2026-03-10T04:38:33+00:0003.09.2026|

Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison

International Journal of Obesity

Junko Yokoi2026-02-24T07:56:10+00:0002.25.2026|

Podocyte specific exon skipping after disease onset improves kidney pathology and function in a mouse model of Alport syndrome

Scientific Reports

Junko Yokoi2025-12-05T03:56:11+00:0011.25.2025|

Differences between Therapeutic Mechanisms of Resmetirom and Semaglutide against MASH in Western Diet-Fed MC4R-Knockout Mice

Scientific Reports

Junko Yokoi2025-11-21T00:07:06+00:0011.20.2025|

Structural characterization and insights into the formation of N-acetylglucosaminylasparagine and its derivatives in NGLY1-deficient models and patients

Glycobiology

Junko Yokoi2025-12-19T07:21:19+00:0010.13.2025|

Hepatotoxicity Reduction Profiles of Antisense Oligonucleotides Containing Amido-Bridged Nucleic Acid and 2′-O,4′-C-Spirocyclopropylene Bridged Nucleic Acid

Nucleic Acid Therapeutics

Junko Yokoi2025-11-21T00:14:03+00:0004.25.2025|

Protein covariation networks for elucidating ferroptosis inducer mechanisms and potential synergistic drug targets

Communications Biology

Junko Yokoi2025-04-01T04:11:28+00:0003.31.2025|

Phosphorylation Dynamics and Kinase Interaction in mRNA Transcription-Associated Kinases: Autophosphorylation of CDK12 and its Modulation by CDK7 and CDK9

BPB Reports

Junko Yokoi2024-11-10T23:35:27+00:0011.06.2024|