Technology Platforms

Chemistry

Chemistry Accelerates Drug Discovery Success

Axcelead leverages our expertise and technologies of rational drug design and synthetic chemistry to create the medicines of the future

  • While it takes a very long time to generate candidate compounds in success at a typical CRO, we accelerate drug discovery in one-stop service with a wealth of experience, technologies and expertise based on a spin-off from pharmaceutical company.
  • We offer full chemistry support in drug discovery across small molecule, peptide and oligonucleotide modality from hit to candidate generation.
  • We provide you innovative and flexible chemistry solutions to the challenges and problems you face by our expertise and technologies.

Our Full Capabilities in Chemistry

Chemistry is at the core of what we do. Our proprietary capabilities offer a wide range of high quality and cost-effective services, aimed at designing the best molecules across a diverse array of assay technologies. Learn more about our full capabilities and how we can partner together.

Medicinal Chemistry

  • “All-in-one” medicinal chemistry with rational design system, advanced synthetic chemistry, and analytical chemistry
  • Extensive experienced scientists with track records leading drug discovery team
  • Experiences in a wide range of therapeutic areas and target classes
  • High-speed and high-quality Design-Make-Test-Analysis (DMTA) cycle close tie-up with Axcelead’s biology, pharmacology, pharmacokinetics, and safety functions
  • Main Services
    – Hit Expansion
    – Lead Generation
    – Lead Optimization

Computational Chemistry

  • Computational chemistry systems
    – SBDD systems
    – LBDD systems
    – Knowledge systems
    – Cheminformatic system
  • AI-driven optimization systems
    – ADMETox prediction models
    – SAR transfer systems
    – Prediction models & structure generative models
  • Internal large-scale computer
    – GPU machines
    – 2000 CPU cluster machines

A-code: In silicon drug discovery technology created by Axcelead

Synthetic Chemistry

High-throughput
parallel synthesis

Approx. 96 parallel
syntheses over 5 to 10 days

Optimal reaction
condition screening

Investigate 48 conditions
within 48 hours

Development of efficient and practical synthetic route

Highly experienced scientists
and excellent facilities

Analytical Chemistry

HPLC

  • Track record: 200+ cases / year
  • Chiral analysis and purification
  • Achiral analysis and purification

SC-XRD

  • Track record: 150+ cases / year
  • Single crystal x-ray diffraction analysis
  • Absolute configuration

NMR

  • Track record: 400+ cases / year
  • 2D NMR (H-H, H-C, H-N, H-F, etc.)
  • High resolution (600MHz)

We are ready to partner with you.