Technology Platforms
High Throughput Screening
We Can Help You Create Truly Novel, Original Drugs
Our integrated High Throughput Screening (HTS) platform, including a pharma-origin library of 1.2+ million compounds, assay development capabilities, and a track record of over 700 projects, helps you rapidly identify your hit compounds.
- We help you identify original and proprietary hits through our 1.2+ million compound library, which originates from a pharmaceutical company and includes 60% internally synthesized compounds
- We can design an efficient hit identification process and prioritize hits by leveraging our accumulated proprietary data
- Our faster, pharma-standard HTS can significantly contribute to reduce drug discovery timeline
Our Full Capabilities in HTS
We have a lot to offer with screening services aimed at identifying new chemical matter. Our team provides high-quality and cost-effective screening services covering a wide range of assay technologies.
Track Record and Experimental Data
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Assay Development
We regularly invest in the best assays and platform technologies to support our customers’ needs in screening activities.
- Offers efficient material preparation and assay development services that enable swift transition to LG/LO stages
- Achieved over 480 track records of assay development, over 80% developed at Axcelead
Typical assay menu examples
Enzyme
– Luminescence, Absorbance, Coupling, Fluorescence, TR-FRET, AlphaScreen
– Label-free assay (Rapidfire-MS)
– ELISA
– Radiometric assay
Protein/Protein Interaction
– TR-FRET, AlphaScreen
– ELISA
– NanoBit, NanoBRET
– Two-hybrid assay
– Biophysical assay
Nucleic Acids
– Biophysical assay (e.g. ASMS)
– Fluorescence probe binding
– FRET
– Cell-based assay (Reporter gene, RT-qPCR)
GPCR
– cAMP assay
– Ca2+ flux assay (FLIPR, FDSS)
– Reporter gene assay
– Arrestin/Internalization assays
– Binding assay
Ion channel / Transporter
– Ion influx assay
– Membrane potential
– Electrophysiology
– Substrate uptake
– Binding
Nuclear Receptor
– Binding assay
– Cofactor recruitment assay
– Reporter gene assay
– Nuclear translocation assay
Phenotype
– High content imaging assay
– Reporter gene assay, qRT-PCR
– Cell growth, etc.
Biophysics
– SPR
– ASMS
– ITC
– Thermal Shift
– Crystal structure
We have comprehensive assay development capability and experience. Please inquire if your assay menu of interest is not covered in this list.
Compound Libraries
- A pharma-origin, high-quality library of 1.2+ million compounds, with 60% originally designed and synthesized compounds
- Diversity library up to 500K compounds
- Focused libraries to support specific needs
Hit Expansion and Hit-to-lead
- Quickly obtain Structure Activity Relationship (SAR) by similar compounds assay selected from 1.2+ million compound library and/or high throughput synthesis
- Determine priority hit compounds by HT-ADMET profiling and assessment by experienced medicinal chemists
- Expand hit compounds to lead rapidly with our full chemistry capabilities and in-silico system