Therapeutic Modalities
Peptide
Our Approach to Overcoming Challenges in Peptide Drug Discovery
A Comprehensive One-Stop Solution for All Your Peptide Drug Discovery Challenges!
Axcelead has intelligent platform technologies to create peptide therapeutics with optimized profiles suitable for clinical development.
These technologies help address challenges in peptide drug discovery, including basic sequence, in vitro activity, in vitro stability, in vivo duration and oral absorption.
Peptide Design
Axcelead creates appropriate peptide sequences with its unique strategies and technologies.
Sequence and scaffold designs
- Sequence designs to improve pharmacological activity
- Sequence designs to improve DMPK
Structural analysis
- Cocrystal structure analysis
- Single-crystal structure analysis
- NMR analysis
In silico analysis
- Identification of hot spots and design proposal
- Binding model analysis and evaluation
- Scaffold design using structure hopping technology
A-code: In silico drug discovery technology createdby Axcelead
Peptide Synthesis
Axcelead has extensive experience in all peptide-related modalities, including multi-cyclic peptides and peptide drug conjugates, to meet your needs.
Synthesis technology
- Multi-sample parallel synthesis
- High-quality bulk synthesis (e.g. for in vivo test)
- Precise and high-speed purification
Modalities
- Short-chain peptides and long-chain peptides
- Cyclic peptides(e.g. bicyclic, tricyclic)
- Modified peptides
- Peptide conjugates
- Peptide prodrugs
- Nonpeptide polyamide
Peptide Evaluation
Axcelead offers comprehensive evaluation services to peptides from multiple perspectives.
Pharmacokinetic and physicochemical property
- Membrane permeability study (PAMPA/Caco-2/MDR1)
- Physicochemical property test (solubility/EPSA/LogD)
- Plasma stability study
- Metabolic stability study
- Pharmacokinetic study
Pharmacology study
- Covers a wide range of therapeutics areas
Preclinical safety evaluation
- Proposes the most efficient strategies
- Manages the entire research, from planning and execution to interpreting results