NAMs Empower Translational Research

In April, the FDA announced that New Approach Methodologies (NAMs) will be encouraged to include in IND applications, while reducing the animal testing requirements. This webinar will provide three key technologies relevant to NAMs. These technologies can be introduced prior to IND or clinical studies.

2026-06-12T07:58:10+00:0010.19.2025|

Lab-in-the-Loop Hit Discovery: Unlocking ‘Undruggable’ Targets with AI-Powered Hit Identification Platform

The discovery of lead compounds for classical druggable targets has become increasingly efficient; however, the development of therapeutics targeting “undruggable” targets continues to face significant hurdles and unmet needs. One of the key challenges in the hit-finding stage is the difficulty in identifying initial hits and obtaining seed compounds that can serve as viable starting points for lead optimization.

2026-06-12T07:54:39+00:0007.11.2025|

Accelerate Targeted Protein Degradation Drug Discovery with Axcelead’s Integrated Platform, DegLead

Targeted Protein Degradation (TPD), including bifunctional degraders and molecular glue degraders, represents a paradigm shift in small molecule drug discovery. However, challenges remain in successfully discovering new TPD drugs. For example, bifunctional degraders face issues such as unfavorable ADME and physicochemical properties due to their molecular complexity. Regarding molecular glue degraders, the discovery of promising compounds often relies heavily on serendipity.

2026-06-12T07:54:02+00:0001.15.2025|
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