Takako Sono of the Discovery Technologies Business Unit to Present a Poster at the 41st Annual Meeting of the Japanese Society for the Study of Xenobiotics

2026.11.04

Takako Sono of the Discovery Technologies Business Unit will present a poster at The 41st Annual Meeting of the Japanese Society for the Study of Xenobiotics, to be held at Kyoto terrsa, Kyoto, Japan. If you plan to attend the conference, we encourage you to join the session and hear the presentation.

Conference Name: The 41st Annual Meeting of the Japanese Society for the Study of Xenobiotics

Date & Time: November 18, 2026 (Wednesday), 17:00–18:00

Location: Tsukuba International Congress Center, Ibaraki, Japan

Title: Development of a Modified Caco-2 Permeability Assay for Targeted Protein

Poster No.: P-004

Presentation Summary
To evaluate beyond-rule-of-five (bRo5) compounds, particularly Targeted Protein Degraders (TPDs), which are difficult to assess using conventional permeability assays, we developed a modified Caco-2 cell-based permeability assay. By extending the assay duration to 24 hours, the correlation with mouse FaFg (fraction absorbed from the gastrointestinal tract) was improved compared with conventional methods. This assay increases the likelihood of detecting permeation for compounds whose transported amounts are below the limit of quantification in conventional assay systems.

Axcelead’s Soulution
The emergence of new modalities such as TPDs has increased the number of compounds that are difficult to evaluate using conventional assay systems. Leveraging extensive experience and a strong technical foundation, Axcelead can design and optimize evaluation systems tailored to the characteristics of customer compounds and their specific development challenges. Please feel free to contact us regarding compounds that are difficult to assess using existing methodologies.